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Domain organization and sequence relationship of killer cell inhibitory receptors
(Blackwell: Immunological Reviews, 1997-02)
Natural killer (NK) cells recognize class I HLA molecules via a family of related receptors composed of two Or three Ig-like domains. Using neighbor-joining analysis of available sequences, groups of these receptors were ...
Transporter associated with antigen-processing-1 (TAP1) alleles in gorilla gorilla: diversification of the locus postspeciation
(Elsevier: Human Immunology, 1996-10)
The transporter associated with antigenprocessing (TAP) proteins are required for the transport of cytosolic peptides into the endoplasmic reticulum for assembly with class I major histocompatibility molecules. In the rat, ...
Structure and content of the major histocompatibility complex (MHC) class I regions of the great anthropoid apes
(Elsevier: Human Immunology, 1996-09)
The origins of the functional class I genes predated human speciation, a phenomenon known as trans-speciation. The retention of class Ia orthologues within the great apes, however, has not been paralleled by studies designed ...
The Pem homeobox gene: rapid evolution of the homeodomain, X chromosomal localization, and expression in reproductive tissue
(Elsevier: Genomics, 1996-06-15)
A hallmark of homeobox genes is their high degree of sequence conservation in distantly related species. Here, we report the chromosomal localization, sequence, and expression pattern of an orphan homeobox gene,Pem,that ...
Identification of new TAP2 alleles in gorilla: evolution of the locus within hominoids
(Springer: Immunogenetics, 1996-06)
Transporters associated with antigen processing molecules (TAP1 and TAP2) mediate the transfer of cytosolic peptides into the lumen of the endoplasmic reticulum for association with newly synthesized class I molecules of ...
The human leukocyte antigen TAP2 gene defines the centromeric limit of melanoma susceptibility on chromosome 6p.
(Blackwell: Tissue Antigens, 1996-02)
A single human leukocyte antigen (HLA) class II allele, DQB1*0301, is strongly associated with melanoma, and the HLA-DR locus provides the telomeric boundary for melanoma susceptibility in the HLA class II region of ...
Rapid direct determination of HLA-DQB1 * 0301 in the whole blood of normal individuals and cancer patients by specific polymerase chain reaction amplification
(Elsevier: Journal of ImmunologicalMethods, 1996)
The HLA class II DQB1 * 0301 allele is present at a higher frequency in patients with malignant melanoma than in Caucasian controls. Furthermore, HLA-DQB1 * 0301 identifies a group of melanoma patients presenting with ...
Mhc-A locus molecules in pygmy chimpanzees: conservation of peptide pockets
(Springer: Immunogenetics, 1995-08)
Structure of CD8 alpha and beta chains of the orangutan: novel patterns of mRNA splicing encoding hingeless polypeptides
(Springer: Immunogenetics, 1992-06)
Gene conversion in the evolution of the human and chimpanzee MHC class I loci.
(Blackwell: Tissue Antigens, 1991-10)
Sixty-five DNA sequences from human and chimpanzee major histocompatibility complex class I loci were searched for statistical evidence of past gene conversion. Twenty-four potential conversions were detected; they were ...