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A functional update of the Escherichia coli K-12 genome
(BioMed Central: Genome Biology, 2001-08-20)
Background: Since the genome of Escherichia coli K-12 was initially annotated in 1997, additional functional information based on biological characterization and functions of sequence-similar proteins has become available. ...
Homology-based annotation yields 1,042 new candidate genes in the Drosophila melanogaster genome
(Nature Publishing Group: Nature Genetics, 2001-03)
The approach to annotating a genome critically affects the number and accuracy of genes identified in the genome sequence. Genome annotation based on stringent gene identification is prone to underestimate the complement ...