Browsing Citations Only by Author "Osier, Michael"

Now showing items 1-8 of 8

    • ALFRED: An allele frequency database for anthropology 

      Osier, Michael; Cheung, Kei-Hoi; Kidd, Judith; Pakstis, Andrew; Miller, Perry; Kidd, Kenneth (Wiley: American Journal of Physical Anthropology, 2002-09)
      The deluge of data from the human genome project (HGP) presents new opportunities for molecular anthropologists to study human variation through the promise of vast numbers of new polymorphisms (e.g., single nucleotide ...

    • ALFRED: the ALelle FREquency Database. Update 

      Rajeevan, H.; Osier, Michael; Cheung, Kei-Hoi; Deng, H.; Druskin, L.; Heinzen, R.; Kidd, J.; Stein, S.; Pakstis, Andrew; Tosches, N.; Yeh, C.; Miller, Perry; Kidd, K. (Oxford University Press: Nucleic Acids Research, 2003-01-01)
      Elaboration of ALFRED (http://alfred.med.yale.edu) is being continued in two directions. One of which is developing tools for efficiently annotating the entries and checking the integrity of the data already in the database ...

    • Allelic variation at alcohol metabolism genes (ADH1B, ADH1C, ALDH2) and alcohol dependence in an American Indian population 

      Mulligan, Connie; Robin, Robert; Osier, Michael; Sambuughin, Nyamkhishig; Goldfarb, Lev; Kittles, Rick; Hesselbrock, Diane; Goldman, David; Long, Jeffrey (Springer: Human Genetics, 2003-09)
      Enzymes encoded by two gene families, alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH), mediate alcohol metabolism in humans. Allelic variants have been identified that alter metabolic rates and influence risk ...

    • A global perspective on genetic variation at the ADH genes reveals unusual patterns of linkage disequilibrium and diversity 

      Osier, Michael; Pakstis, Andrew; Soodyall, Himla; Comas, David; Goldman, David; Odunsi, Adekunle; Okonofua, Friday; Parnas, Josef; Schulz, Leslie; Bertranpetit, Jaume; Bonne-Tamir, Batsheva; Lu, Ru-Band; Kidd, Judith; Kidd, Kenneth (University of Chicago Press: American Journal of Human Genetics, 2002-07)
      Variants of different Class I alcohol dehydrogenase (ADH) genes have been shown to be associated with an effect that is protective against alcoholism. Previous work from our laboratory has shown that the two sites showing ...

    • Handling multiple testing while interpreting microarrays with the Gene Ontology Database 

      Osier, Michael; Zhao, Hongyu; Cheung, Kei-Hoi (BioMed Central: BMC Bioinformatics, 2004-09-06)
      Background The development of software tools that analyze microarray data in the context of genetic knowledgebases is being pursued by multiple research groups using different methods. A common problem for many of these ...

    • A high productivity/low maintenance approach to high-performance computation for biomedicine: four case studies 

      Carriero, Nicholas; Osier, Michael; Cheung, Kei-Hoi; Miller, Perry; Gerstein, Mark; Zhao, Hongyu; Wu, Baolin; Rifkin, Scott; Chang, Joseph; Zhang, Heping; White, Kevin; Williams, Kenneth; Schultz, Martin (American Medical Informatics Association: Journal of the American Medical Informatics Association, 2005-01)
      The rapid advances in high-throughput biotechnologies such as DNA microarrays and mass spectrometry have generated vast amounts of data ranging from gene expression to proteomics data. The large size and complexity involved ...

    • Possible epistatic role of ADH7 in the protection against alcoholism 

      Osier, Michael; Lu, Ru-Band; Pakstis, Andrew; Kidd, J.; Huang, S.; Kidd, K. (Wiley: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 2004-04-01)
      In recent studies of the role of the alcohol dehydrogenase genes (ADH) in alcoholism the ADH1B Arg47His polymorphism appears to affect risk via a protective effect associated with the ADH1B*47His. Here we present evidence ...

    • Proline-threonine substitution in codon 351 of ADH1C is common in Native Americans. 

      Osier, Michael; Pakstis, Andrew; Goldman, David; Edenberg, Howard; Kidd, Judith; Kidd, Kenneth (Blackwell: Alcoholism: Clinical & Experimental Research, 2002-12)
      Background: The alcohol dehydrogenase (ADH) genes have been repeatedly associated with protection against alcoholism. Until now, only four protein coding variants have been identified (ADH1C Arg271Gln, Ile349Val, ADH1B ...