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    • Acylhydrazones as M1/M3 selective muscarinic agonists 

      Wu, E.; Kover, A.; Loch, J.; Rosenberg, L.; Semus, S.; Verhoest, P.; Gordon, J.; Machulskis, A.; McCreedy, S.; Zongrone, J.; Blosser, J. (Elsevier: Bioorganic and Medicinal Chemistry Letters, 1996-11-05)
      To improve receptor binding affinity and to investigate functional selectivity of 2,8-dimethyl-1-oxa-8- azaspiro[4.5]decan-3-one acetylhydrazone 2 at muscarinic receptor subtypes, a series of acylhydrazones A was synthesized. ...