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dc.contributor.authorEvans, Ireneen_US
dc.contributor.authorGross, Paulen_US
dc.date.accessioned2006-08-14T14:36:09Zen_US
dc.date.available2006-08-14T14:36:09Zen_US
dc.date.issued1978-06en_US
dc.identifier.citationExperimental Cell Research 114N1 (1978) 85-93en_US
dc.identifier.issn0014-4827en_US
dc.identifier.urihttp://hdl.handle.net/1850/2275en_US
dc.description.abstractDevelopment of Arbacia punctulata embryos in the presence of bromodeoxyuridine (BUdR) was investigated under conditions which allowed about 20% substitution of BUdR for thymidine residues in DNA. Development was essentially normal from fertilization to the feeding larva. There appeared to be no restricted stretches of DNA which failed to incorporate BUdR. Even very early stages were permeable to BUdR, which entered all the nuclei. The failure of BUdR substitution to block development in Arbacia is discussed in the light of evidence that this analogue blocks the onset of differentiative product synthesis in many cellular systems.en_US
dc.description.sponsorshipThis investigation was supported in part by USNCI Grant Number CA-11198 and by NICHD Grant Number HD-08652-02, 03.en_US
dc.format.extent37365 bytesen_US
dc.format.mimetypeapplication/pdfen_US
dc.language.isoen_USen_US
dc.publisherElsevier: Experimental Cell Researchen_US
dc.title5-Bromodeoxyuridine does not affect development of the sea urchin, Arbacia punctulataen_US
dc.typeArticleen_US
dc.subject.keywordBUdRen_US
dc.subject.keywordDevelopmenten_US
dc.subject.keywordSea urchinsen_US
dc.identifier.urlhttp://dx.doi.org/10.1016/0014-4827(78)90039-3


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