A computational investigation of kinetoplastid trans-splicing
Date
2005-10-17Author
Gopal, Shuba
Awadalla, Saria
Gaasterland, Terry
Cross, George
Metadata
Show full item recordAbstract
Trans-splicing is an unusual process in which two separate RNA strands are spliced together to yield a mature mRNA. We present a novel computational approach which has an overall accuracy of 82% and can predict 92% of known trans-splicing sites. We have applied our method to chromosomes 1 and 3 of Leishmania major, with high-confidence predictions for 85% and 88% of annotated genes respectively. We suggest some extensions of our method to other systems.