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dc.contributor.authorOsier, Michaelen_US
dc.contributor.authorPakstis, Andrewen_US
dc.contributor.authorGoldman, Daviden_US
dc.contributor.authorEdenberg, Howarden_US
dc.contributor.authorKidd, Judithen_US
dc.contributor.authorKidd, Kennethen_US
dc.date.accessioned2006-08-21T19:47:41Zen_US
dc.date.available2006-08-21T19:47:41Zen_US
dc.date.issued2002-12en_US
dc.identifier.citationAlcoholism: Clinical & Experimental Research 26N12 (2002) 1759-1763en_US
dc.identifier.issn1530-0277en_US
dc.identifier.urihttp://hdl.handle.net/1850/2377en_US
dc.description.abstractBackground: The alcohol dehydrogenase (ADH) genes have been repeatedly associated with protection against alcoholism. Until now, only four protein coding variants have been identified (ADH1C Arg271Gln, Ile349Val, ADH1B Arg47His, and Arg369Cys), and only two of these (ADH1C Ile349Val and ADH1B Arg47His) have been routinely tested in association studies with alcoholism. Methods: The new ADH1C*351Thr allele was identified by direct sequencing of DNA samples that gave different typing results for the ADH1C Ile349Val polymorphism with different typing protocols. Results: A new coding variant has been identified at codon 351 of ADH1C. This allele is found in most Native American populations that we have studied with allele frequencies of the new ADH1C*351Thr allele as high as 26%. Only two instances of this allele have been seen in a large survey of African and Eurasian populations. Conclusions: The changes in charge, size, and rotational mobility caused by this amino acid substitution should be significant. Because this new variant codes for a new enzyme form in Native Americans, the kinetics of this enzyme should be studied and considered in studies of the role of ADH1C in the protection against alcoholism in Native Americans.en_US
dc.format.extent29143 bytesen_US
dc.format.mimetypeapplication/pdfen_US
dc.language.isoen_USen_US
dc.publisherBlackwell: Alcoholism: Clinical & Experimental Researchen_US
dc.subjectAlcohol dehydrogenaseen_US
dc.subjectAllelesen_US
dc.subjectNative Americansen_US
dc.subjectADHen_US
dc.titleProline-threonine substitution in codon 351 of ADH1C is common in Native Americans.en_US
dc.typeArticleen_US
dc.identifier.urlhttp://dx.doi.org/10.1111/j.1530-0277.2002.tb02481.x


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