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Variation in the type I interferon gene cluster on 9p21 influences susceptibility to asthma and atopy

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dc.contributor.author Chan, A. en_US
dc.contributor.author Newman, Dina en_US
dc.contributor.author Shon, A. en_US
dc.contributor.author Schneider, Donald en_US
dc.contributor.author Kuldanek, S. en_US
dc.contributor.author Ober, Carole en_US
dc.date.accessioned 2006-08-21T19:49:23Z en_US
dc.date.available 2006-08-21T19:49:23Z en_US
dc.date.issued 2006-03-08 en_US
dc.identifier.citation Genes and Immunity 7N2 (2006) 169-178 en_US
dc.identifier.issn 1476-5470 en_US
dc.identifier.uri http://hdl.handle.net/1850/2383 en_US
dc.description.abstract A genome-wide screen for asthma and atopy susceptibility alleles conducted in the Hutterites, a founder population of European descent, reported evidence of linkage with a short tandem repeat polymorphism (STRP) within the type I interferon (IFN) gene cluster on chromosome 9p21. The goal of this study was to identify variation within the IFN gene cluster that influences susceptibility to asthma and atopic phenotypes. We screened approximately 25 kb of sequence, including the flanking sequence of all 15 functional genes and the single coding exon in 12, in Hutterites representing different IFNA-STRP genotypes. We identified 78 polymorphisms, and genotyped 40 of these (in 14 genes) in a large Hutterite pedigree. Modest associations (0.003<P<0.05) with asthma, bronchial hyper-responsiveness (BHR), and atopy were observed with individual variants or genes, spanning the entire 400 kb region. However, pairwise combinations of haplotypes between genes showed highly significant associations with different phenotypes (P<10-5) that were localized to specific pairs of genes or regions of this cluster. These results suggest that variation in multiple genes in the type I IFN cluster on 9p22 contribute to asthma and atopy susceptibility, and that not all genes contribute equally to all phenotypes. en_US
dc.description.sponsorship This work was supported by NIH Grants HL56399 and HL66533. en_US
dc.format.extent 27604 bytes en_US
dc.format.mimetype application/pdf en_US
dc.language.iso en_US en_US
dc.publisher Nature Publishing Group: Genes and Immunity en_US
dc.subject Asthma en_US
dc.subject Atopy en_US
dc.subject Hutterites en_US
dc.subject Type I interferons en_US
dc.title Variation in the type I interferon gene cluster on 9p21 influences susceptibility to asthma and atopy en_US
dc.type Article en_US
dc.identifier.url http://dx.doi.org/10.1038/sj.gene.6364287

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