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Are common disease susceptibility alleles the same in outbred and founder populations?

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dc.contributor.author Newman, Dina en_US
dc.contributor.author Hoffjan, Sabine en_US
dc.contributor.author Bourgain, Catherine en_US
dc.contributor.author Abney, Mark en_US
dc.contributor.author Nicolae, Raluca en_US
dc.contributor.author Profits, Elle en_US
dc.contributor.author Grow, Michael en_US
dc.contributor.author Walker, Karen en_US
dc.contributor.author Steiner, Lori en_US
dc.contributor.author Parry, Rodney en_US
dc.contributor.author Reynolds, Rebecca en_US
dc.contributor.author McPeek, Mary en_US
dc.contributor.author Cheng, Suzanne en_US
dc.contributor.author Ober, Carole en_US
dc.date.accessioned 2006-08-21T19:49:39Z en_US
dc.date.available 2006-08-21T19:49:39Z en_US
dc.date.issued 2004-07 en_US
dc.identifier.citation Journal of Human Genetics 12N7 (2004) 584-590 en_US
dc.identifier.issn 1476-5438 en_US
dc.identifier.uri http://hdl.handle.net/1850/2384 en_US
dc.description.abstract Founder populations have been the subjects of complex disease studies because of their decreased genetic heterogeneity, increased linkage disequilibrium and more homogeneous environmental exposures. However, it is possible that disease alleles identified in founder populations may not contribute significantly to susceptibility in outbred populations. In this study we examine the Hutterites, a founder population of European descent, for 103 polymorphisms in 66 genes that are candidates for cardiovascular or inflammatory diseases. We compare the frequencies of alleles at these loci in the Hutterites to their frequencies in outbred European-American populations and test for associations with cardiovascular disease-associated phenotypes in the Hutterites. We show that alleles at these loci are found at similar frequencies in the Hutterites and in outbred populations. In addition, we report associations between 39 alleles or haplotypes and cardiovascular disease phenotypes (P<0.05), with five loci remaining significant after adjusting for multiple comparisons. These data indicate that this founder population is informative and offers considerable advantages for genetic studies of common complex diseases. en_US
dc.format.extent 27604 bytes en_US
dc.format.mimetype application/pdf en_US
dc.language.iso en_US en_US
dc.publisher Nature Publishing Group: European Journal of Human Genetics en_US
dc.subject Cardiovascular disease en_US
dc.subject Disease alleles en_US
dc.subject Founder populations en_US
dc.subject Inflammatory disease en_US
dc.title Are common disease susceptibility alleles the same in outbred and founder populations? en_US
dc.type Article en_US
dc.identifier.url http://dx.doi.org/10.1038/sj.ejhg.5201191

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