A transposable epitope of HLA-137, B40 molecules
dc.contributor.advisor | Monoclonal antibodies | en_US |
dc.contributor.advisor | Protein structure | en_US |
dc.contributor.author | Ways, Judy | en_US |
dc.contributor.author | Lawlor, David | en_US |
dc.contributor.author | Wan, Anne | en_US |
dc.contributor.author | Parham, Peter | en_US |
dc.date.accessioned | 2006-08-21T19:55:37Z | en_US |
dc.date.available | 2006-08-21T19:55:37Z | en_US |
dc.date.issued | 1987-05 | en_US |
dc.identifier.citation | Immunogenetics 25N5 (1987) 323-328 | en_US |
dc.identifier.issn | 1432-1211 | en_US |
dc.identifier.uri | http://hdl.handle.net/1850/2407 | en_US |
dc.description.abstract | The monoclonal antibody M1340.2 defines a novel subtype of HLA-1340 that is expressed by the Sweig cell line. This molecule, called HLA-B40*, lacks an antigenic determinant that is common to HLA-137 and the HLA-Bw60 subtype of HLA-1340. Genes encoding HLA-B40* and HLA-BW60 have now been isolated and the amino acid sequences of these proteins compared with other HLA-13 locus molecules. These results show that HLA-B40* is a unique protein which differs from HLA-BW60 by eight amino acid substitutions. Comparison of the sequences for HLA-B40*, -Bw60, and -B7 localizes the MB40.2 epitope to a cluster of three substitutions at positions 177, 178, and 180 at the end of the 2 domain. Gene conversion or reciprocal recombination are postulated to have transferred this cluster of substitutions, and their associated epitope, during the evolution of HLA-B locus genes. The epitope may consist of an a helical segment which is exclusively found on MB40.2-positive molecules. | en_US |
dc.format.extent | 43151 bytes | en_US |
dc.format.mimetype | application/pdf | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | Springer: Immunogenetics | en_US |
dc.title | A transposable epitope of HLA-137, B40 molecules | en_US |
dc.type | Article | en_US |
dc.subject.keyword | HLA antigens | en_US |
dc.identifier.url | http://dx.doi.org/10.1007/BF00404425 |
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