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ALFRED: An allele frequency database for anthropology

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dc.contributor.author Osier, Michael en_US
dc.contributor.author Cheung, Kei-Hoi en_US
dc.contributor.author Kidd, Judith en_US
dc.contributor.author Pakstis, Andrew en_US
dc.contributor.author Miller, Perry en_US
dc.contributor.author Kidd, Kenneth en_US
dc.date.accessioned 2006-08-22T16:26:03Z en_US
dc.date.available 2006-08-22T16:26:03Z en_US
dc.date.issued 2002-09 en_US
dc.identifier.citation American Journal of Physical Anthropology 119N1 (2002) 77-83 en_US
dc.identifier.issn 1096-8644 en_US
dc.identifier.uri http://hdl.handle.net/1850/2424 en_US
dc.description.abstract The deluge of data from the human genome project (HGP) presents new opportunities for molecular anthropologists to study human variation through the promise of vast numbers of new polymorphisms (e.g., single nucleotide polymorphisms or SNPs). Collecting the resulting data into a single, easily accessible resource will be important to facilitate this research. We created a prototype Web-accessible database named ALFRED (ALelle FREquency Database, http://alfred.med.yale.edu/alfred/) to store and make publicly available allele frequency data on diverse polymorphic sites for many populations. In constructing this database, we considered many different concerns relating to the types of information needed for anthropology, population genetics, molecular genetics, and statistics, as well as issues of data integrity and ease of access to data. We also developed links to other Web-based databases as well as procedures for others to make links to the data in ALFRED. Here we present an overview of the issues considered and provisional solutions, as well as an example of data already available. It is our hope that this database will be useful for research and teaching in a wide range of fields, and that colleagues from various fields will contribute to making ALFRED an important resource for many studies as yet unforeseen. en_US
dc.description.sponsorship NSF; Grant Number: 9912028, 9632509, BCS0096588 and NIGMS; Grant Number: GM57672 and NIAAA; Grant Number: AA09379 en_US
dc.format.extent 26196 bytes en_US
dc.format.mimetype application/pdf en_US
dc.language.iso en_US en_US
dc.publisher Wiley: American Journal of Physical Anthropology en_US
dc.title ALFRED: An allele frequency database for anthropology en_US
dc.type Article en_US
dc.identifier.url http://dx.doi.org/10.1002/ajpa.10094

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