dc.contributor.author | Collison, Christina | |
dc.contributor.author | Chen, Jian | |
dc.contributor.author | Walvoord, Ryan | |
dc.date.accessioned | 2008-12-09T14:04:14Z | |
dc.date.available | 2008-12-09T14:04:14Z | |
dc.date.issued | 2006 | |
dc.identifier.citation | Synthesis 2006N14 (2006) 2319-2322 | en_US |
dc.identifier.issn | 1437-210x | |
dc.identifier.uri | http://hdl.handle.net/1850/7658 | |
dc.description.abstract | Montiporyne E, a novel diacetylenic lactam isolated from the stony coral Montipora sp., was shown to exhibit cytotoxicity against certain solid tumor cells. Construction of a suitably functionalized α,β-unsaturated lactam for palladium-catalyzed couplings was realized via a Beckmann rearrangement. Subsequent Sonagoshira coupling with a known alkyne chain efficiently afforded the alleged structure of the natural product. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | Georg Thieme Verlag | en_US |
dc.relation.ispartofseries | vol. 2006 | en_US |
dc.relation.ispartofseries | no. 14 | en_US |
dc.subject | Alkynes | en_US |
dc.subject | Beckmann | en_US |
dc.subject | Coupling reactions | en_US |
dc.subject | Lactams | en_US |
dc.subject | Synthesis | en_US |
dc.title | The First total synthesis of the proposed structure of Montiporyne E | en_US |
dc.type | Article | en_US |
dc.identifier.url | http://dx.doi.org/10.1055/s-2006-942441 | |