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Genome-wide association study identifies ITGB3 as a QTL for whole blood serotonin
(Nature Publishing Group: European Journal of Human Genetics, 2004-11)
Serotonin has been implicated in common disorders involving the central nervous, gastrointestinal, cardiovascular, and pulmonary systems. We describe the first genome-wide screen to identify quantitative trait loci (QTLs) ...
Are common disease susceptibility alleles the same in outbred and founder populations?
(Nature Publishing Group: European Journal of Human Genetics, 2004-07)
Founder populations have been the subjects of complex disease studies because of their decreased genetic heterogeneity, increased linkage disequilibrium and more homogeneous environmental exposures. However, it is possible ...
Major loci influencing serum triglyceride levels on 2q14 and 9p21 localized by homozygosity-by-descent mapping in a large Hutterite pedigree
(Oxford University Press: Human Molecular Genetics, 2003-01-15)
Serum triglyceride (TG) level is a well-known risk factor for cardiovascular disease, a leading cause of morbidity and mortality in Western countries. Although genome-wide scans for TG have been conducted in several ...
The importance of genealogy in determining genetic associations with complex traits
(University of Chicago Press: American Journal of Human Genetics, 2001-11)