Genome-wide association study identifies ITGB3 as a QTL for whole blood serotonin
Date
2004-11Author
Weiss, Lauren
Veenstra-VanderWeele, Jeremy
Newman, Dina
Kim, Soo-Jeong
Dytch, Harvey
McPeek, Mary
Cheng, Suzanne
Ober, Carole
Cook, Edwin Jr.
Abney, Mark
Metadata
Show full item recordAbstract
Serotonin has been implicated in common disorders involving the central nervous, gastrointestinal, cardiovascular, and pulmonary systems. We describe the first genome-wide screen to identify quantitative trait loci (QTLs) influencing whole blood serotonin in 567 members of a single large pedigree, using a novel association-based mapping approach. We identified an association between the beta 3 integrin (ITGB3) Leu33Pro polymorphism on 17q21 and whole blood serotonin levels (P-value=9.8 ´ 10-5). This variant explained the evidence for linkage in this region when included as a covariate in the linkage analysis (change in LOD from 1.87 to 0.16), indicating that ITGB3 may be an important serotonin QTL.