dc.contributor.author | Weiss, Lauren | en_US |
dc.contributor.author | Veenstra-VanderWeele, Jeremy | en_US |
dc.contributor.author | Newman, Dina | en_US |
dc.contributor.author | Kim, Soo-Jeong | en_US |
dc.contributor.author | Dytch, Harvey | en_US |
dc.contributor.author | McPeek, Mary | en_US |
dc.contributor.author | Cheng, Suzanne | en_US |
dc.contributor.author | Ober, Carole | en_US |
dc.contributor.author | Cook, Edwin Jr. | en_US |
dc.contributor.author | Abney, Mark | en_US |
dc.date.accessioned | 2006-08-21T19:49:55Z | en_US |
dc.date.available | 2006-08-21T19:49:55Z | en_US |
dc.date.issued | 2004-11 | en_US |
dc.identifier.citation | European Journal of Human Genetics 12N11 (2004) 949-954 | en_US |
dc.identifier.issn | 1476-5438 | en_US |
dc.identifier.uri | http://hdl.handle.net/1850/2385 | en_US |
dc.description.abstract | Serotonin has been implicated in common disorders involving the central nervous, gastrointestinal, cardiovascular, and pulmonary systems. We describe the first genome-wide screen to identify quantitative trait loci (QTLs) influencing whole blood serotonin in 567 members of a single large pedigree, using a novel association-based mapping approach. We identified an association between the beta 3 integrin (ITGB3) Leu33Pro polymorphism on 17q21 and whole blood serotonin levels (P-value=9.8 ´ 10-5). This variant explained the evidence for linkage in this region when included as a covariate in the linkage analysis (change in LOD from 1.87 to 0.16), indicating that ITGB3 may be an important serotonin QTL. | en_US |
dc.format.extent | 27604 bytes | en_US |
dc.format.mimetype | application/pdf | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | Nature Publishing Group: European Journal of Human Genetics | en_US |
dc.subject | Genome-wide association | en_US |
dc.subject | Integrin | en_US |
dc.subject | Serotonin | en_US |
dc.title | Genome-wide association study identifies ITGB3 as a QTL for whole blood serotonin | en_US |
dc.type | Article | en_US |
dc.identifier.url | http://dx.doi.org/10.1038/sj.ejhg.5201239 | |