Browsing Citations Only by Author "Gopal, Shuba"

Now showing items 1-7 of 7

    • ATP-Dependent colchicine transport by human erythrocyte glutathione conjugate transporter 

      Awasthi, S.; Singhal, S.; Pandya, U.; Gopal, Shuba; Zimniak, P.; Singh, S.; Awasthi, Y. (Elsevier: Toxicology and Applied Pharmacology, 1999-03)
      We have recently demonstrated mutually inhibitory ATP-dependent transport of dinitrophenyl-S-glutathione (DNP-SG) and doxorubicin by DNP-SG ATPase purified from human erythrocyte membranes (S. Awasthi et al., 1998a,b). Our ...

    • A computational investigation of kinetoplastid trans-splicing 

      Gopal, Shuba; Awadalla, Saria; Gaasterland, Terry; Cross, George (BioMed Central: Genome Biology, 2005-10-17)
      Trans-splicing is an unusual process in which two separate RNA strands are spliced together to yield a mature mRNA. We present a novel computational approach which has an overall accuracy of 82% and can predict 92% of known ...

    • A functional update of the Escherichia coli K-12 genome 

      Serres, Margrethe; Gopal, Shuba; Nahum, Laila; Liang, Ping; Gaasterland, Terry; Riley, Monica (BioMed Central: Genome Biology, 2001-08-20)
      Background: Since the genome of Escherichia coli K-12 was initially annotated in 1997, additional functional information based on biological characterization and functions of sequence-similar proteins has become available. ...

    • Genetic algorithm learning as a robust approach to RNA editing site prediction 

      Thompson, James; Gopal, Shuba (BioMed Central: BMC Bioinformatics, 2006-03-16)
      Background: RNA editing is one of several post-transcriptional modifications that may contribute to organismal complexity in the face of limited gene complement in a genome. One form, known as C -> U editing, appears to ...

    • Homology-based annotation yields 1,042 new candidate genes in the Drosophila melanogaster genome 

      Gopal, Shuba; Schroeder, Mark; Pieper, Ursula; Sczyrba, Alexander; Aytekin-Kurban, Gulriz; Bekiranov, Stefan; Fajardo, Eduardo; Eswar, Narayanan; Sanchez, Roberto; Sali, Andrej; Gaasterland, Terry (Nature Publishing Group: Nature Genetics, 2001-03)
      The approach to annotating a genome critically affects the number and accuracy of genes identified in the genome sequence. Genome annotation based on stringent gene identification is prone to underestimate the complement ...

    • Optimised isolation procedure for biologically active compounds nimbolide and 28-deoxonimbolide from Azadirachta indica leaves 

      Nair, M.; Gopal, Shuba; Isaac, D. (Elsevier: Phytochemistry, 1999-12)
      Alpha-linolenic acid has been isolated from fresh A. indica leaves and an optimised procedure for the isolation of the limonoids nimbolide and 28-deoxonimbolide is described.

    • An organism-specific method to rank predicted coding regions in Trypanosoma brucei 

      Gopal, Shuba; Cross, George; Gaasterland, Terry (Oxford University Press: Nucleic Acids Research, 2003)
      Genome annotation in differently evolved organisms presents challenges because the lack of sequence-based homology limits the ability to determine the function of putative coding regions. To provide an alternative to ...