Browsing Citations Only by Author "Ober, Carole"

Now showing items 1-6 of 6

    • Are common disease susceptibility alleles the same in outbred and founder populations? 

      Newman, Dina; Hoffjan, Sabine; Bourgain, Catherine; Abney, Mark; Nicolae, Raluca; Profits, Elle; Grow, Michael; Walker, Karen; Steiner, Lori; Parry, Rodney; Reynolds, Rebecca; McPeek, Mary; Cheng, Suzanne; Ober, Carole (Nature Publishing Group: European Journal of Human Genetics, 2004-07)
      Founder populations have been the subjects of complex disease studies because of their decreased genetic heterogeneity, increased linkage disequilibrium and more homogeneous environmental exposures. However, it is possible ...

    • Genetic variation in immunoregulatory pathways and atopic phenotypes in infancy 

      Hoffjan, Sabine; Ostrovnaja, Irina; Nicolae, Dan; Newman, Dina; Nicolae, Raluca; Gangnon, Ronald; Steiner, Lori; Walker, Karen; Reynolds, Rebecca; Greene, Deborah; Mirel, Daniel; Gern, James; Lemanske, Robert; Ober, Carole (Elsevier: The Journal of Allergy and Clinical Immunology, 2004-03)
      Background: Asthma is a chronic respiratory disease that often originates in early childhood. Although candidate gene studies have identified many potential asthma susceptibility genes in adult populations, few have studied ...

    • Genome-wide association study identifies ITGB3 as a QTL for whole blood serotonin 

      Weiss, Lauren; Veenstra-VanderWeele, Jeremy; Newman, Dina; Kim, Soo-Jeong; Dytch, Harvey; McPeek, Mary; Cheng, Suzanne; Ober, Carole; Cook, Edwin Jr.; Abney, Mark (Nature Publishing Group: European Journal of Human Genetics, 2004-11)
      Serotonin has been implicated in common disorders involving the central nervous, gastrointestinal, cardiovascular, and pulmonary systems. We describe the first genome-wide screen to identify quantitative trait loci (QTLs) ...

    • The importance of genealogy in determining genetic associations with complex traits 

      Newman, Dina; Abney, Mark; McPeek, Mary; Ober, Carole; Cox, Nancy (University of Chicago Press: American Journal of Human Genetics, 2001-11)

    • Major loci influencing serum triglyceride levels on 2q14 and 9p21 localized by homozygosity-by-descent mapping in a large Hutterite pedigree 

      Newman, Dina; Abney, Mark; Dytch, Harvey; Parry, Rodney; McPeek, Mary; Ober, Carole (Oxford University Press: Human Molecular Genetics, 2003-01-15)
      Serum triglyceride (TG) level is a well-known risk factor for cardiovascular disease, a leading cause of morbidity and mortality in Western countries. Although genome-wide scans for TG have been conducted in several ...

    • Variation in the type I interferon gene cluster on 9p21 influences susceptibility to asthma and atopy 

      Chan, A.; Newman, Dina; Shon, A.; Schneider, Donald; Kuldanek, S.; Ober, Carole (Nature Publishing Group: Genes and Immunity, 2006-03-08)
      A genome-wide screen for asthma and atopy susceptibility alleles conducted in the Hutterites, a founder population of European descent, reported evidence of linkage with a short tandem repeat polymorphism (STRP) within the ...