Citations Only: Recent submissions
Now showing items 661-680 of 990
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Structure and content of the major histocompatibility complex (MHC) class I regions of the great anthropoid apes
(Elsevier: Human Immunology, 1996-09)The origins of the functional class I genes predated human speciation, a phenomenon known as trans-speciation. The retention of class Ia orthologues within the great apes, however, has not been paralleled by studies designed ... -
Non-hydrolytic release of iron from ferrienterobactin analogs by extracts of bacillus subtilis
(Elsevier: Biochemical and Biophysical Research Communications, 1980-12-31)The ferric chelates of the microbial siderophore enterobactin and of two synthetic analogs of enterobactin were sources of iron for growth of Bacillus subtilis WB2802. The ferrisiderophore reductase system in cell-free ... -
Human follicular fluid and mouse cumulus cells act synergistically to enhance preimplantation mouse Balb/cJ embryo development
(Springer: Journal of Assisted Reproduction and Genetics, 1995-11)Problem The development of preimplantation mammalian embryos in vitro is less than optimal. Follicular fluid and cumulus cells have both been used, independently, to improve preimplantation embryo quality in culture. Method ... -
Purification of human myeloperoxidase by Concanavalin A-Sepharose affinity chromatography.
(Marcel Dekker: Preparative Biochemistry, 1980)Myeloperoxidase (E.C. 1.11.1.7. Donor: H2O2 oxidoreductase), an enzyme of the azurophil granule of polymorphonuclear leukocytes, has been purified from the blood of a single human donor. Leukocytes were harvested by dextran ... -
Histochemical and biochemical studies of the hepatopancreas peroxidase of the freshwater crayfish, Cambarus robustus
(Wiley: Journal of Morphology, 1985-05)Crayfish are among the few invertebrate species reported to possess endogenous peroxidase activity. The enzyme is found within the hepatopancreas, the principal digestive and absorptive organ of the crustacean body. Cambarus ... -
Crayfish hepatopancreas peroxidase: Absence of a microbicidal function
(Elsevier: Journal of Invertebrate Pathology, 1980-03) -
Major loci influencing serum triglyceride levels on 2q14 and 9p21 localized by homozygosity-by-descent mapping in a large Hutterite pedigree
(Oxford University Press: Human Molecular Genetics, 2003-01-15)Serum triglyceride (TG) level is a well-known risk factor for cardiovascular disease, a leading cause of morbidity and mortality in Western countries. Although genome-wide scans for TG have been conducted in several ... -
Differential fiu–lacZ fusion regulation linked to Escherichia coli colony development
(Blackwell: Molecular Microbiology, 1999-07)Colonies of strains carrying a stable λplacMu15 translational fusion displayed sharply defined intense staining at the centre on Xgal medium. The fusion was in fiu (ferric ion uptake), encoding an iron-regulated outer ... -
Genome-wide association study identifies ITGB3 as a QTL for whole blood serotonin
(Nature Publishing Group: European Journal of Human Genetics, 2004-11)Serotonin has been implicated in common disorders involving the central nervous, gastrointestinal, cardiovascular, and pulmonary systems. We describe the first genome-wide screen to identify quantitative trait loci (QTLs) ... -
Are common disease susceptibility alleles the same in outbred and founder populations?
(Nature Publishing Group: European Journal of Human Genetics, 2004-07)Founder populations have been the subjects of complex disease studies because of their decreased genetic heterogeneity, increased linkage disequilibrium and more homogeneous environmental exposures. However, it is possible ... -
Variation in the type I interferon gene cluster on 9p21 influences susceptibility to asthma and atopy
(Nature Publishing Group: Genes and Immunity, 2006-03-08)A genome-wide screen for asthma and atopy susceptibility alleles conducted in the Hutterites, a founder population of European descent, reported evidence of linkage with a short tandem repeat polymorphism (STRP) within the ... -
Genetic variation in immunoregulatory pathways and atopic phenotypes in infancy
(Elsevier: The Journal of Allergy and Clinical Immunology, 2004-03)Background: Asthma is a chronic respiratory disease that often originates in early childhood. Although candidate gene studies have identified many potential asthma susceptibility genes in adult populations, few have studied ... -
The importance of genealogy in determining genetic associations with complex traits
(University of Chicago Press: American Journal of Human Genetics, 2001-11) -
Allelic variation at alcohol metabolism genes (ADH1B, ADH1C, ALDH2) and alcohol dependence in an American Indian population
(Springer: Human Genetics, 2003-09)Enzymes encoded by two gene families, alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH), mediate alcohol metabolism in humans. Allelic variants have been identified that alter metabolic rates and influence risk ... -
Proline-threonine substitution in codon 351 of ADH1C is common in Native Americans.
(Blackwell: Alcoholism: Clinical & Experimental Research, 2002-12)Background: The alcohol dehydrogenase (ADH) genes have been repeatedly associated with protection against alcoholism. Until now, only four protein coding variants have been identified (ADH1C Arg271Gln, Ile349Val, ADH1B ... -
Handling multiple testing while interpreting microarrays with the Gene Ontology Database
(BioMed Central: BMC Bioinformatics, 2004-09-06)Background The development of software tools that analyze microarray data in the context of genetic knowledgebases is being pursued by multiple research groups using different methods. A common problem for many of these ... -
A high productivity/low maintenance approach to high-performance computation for biomedicine: four case studies
(American Medical Informatics Association: Journal of the American Medical Informatics Association, 2005-01)The rapid advances in high-throughput biotechnologies such as DNA microarrays and mass spectrometry have generated vast amounts of data ranging from gene expression to proteomics data. The large size and complexity involved ... -
Possible epistatic role of ADH7 in the protection against alcoholism
(Wiley: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 2004-04-01)In recent studies of the role of the alcohol dehydrogenase genes (ADH) in alcoholism the ADH1B Arg47His polymorphism appears to affect risk via a protective effect associated with the ADH1B*47His. Here we present evidence ... -
A functional update of the Escherichia coli K-12 genome
(BioMed Central: Genome Biology, 2001-08-20)Background: Since the genome of Escherichia coli K-12 was initially annotated in 1997, additional functional information based on biological characterization and functions of sequence-similar proteins has become available. ... -
Homology-based annotation yields 1,042 new candidate genes in the Drosophila melanogaster genome
(Nature Publishing Group: Nature Genetics, 2001-03)The approach to annotating a genome critically affects the number and accuracy of genes identified in the genome sequence. Genome annotation based on stringent gene identification is prone to underestimate the complement ...